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pentobarbital will reduce the extent or result of fedratinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Outcome of coadministering a powerful CYP3A4 inducer with fedratinib has not been studied.pentobarbital will lower the level or effect of brexpiprazole by affecting hepatic/intestinal enzyme CYP3A4 me